DNA Stuhl-Test

[J.P.Theurich]

Sehr geehrte Experten,
welche Bedeutung kommt derzeit dem genetischen Stuhltest beim Kolon-CA zu ?
Ist die Sensitivität immer noch schlecht ?
Oder trifft er besser die hereditären Formen ?
Wird der Test bereits in Europa vertrieben ?

[Prof. Wust]

RE: DNA Stuhl-Test


Der von Ihnen angeführte Test spielt in der praktischen Früherkennung keine Rolle und ist mir, offen gestanden, nicht bekannt. Genetische Tests spielen eine Rolle bei der Ermittlung von he-reditären Karzinomformen. Dies sind aber unter 10% der Gesamtzahl beim Kolon-Ca. Im Stuhl wird der Hämokkult-Test (auf Blut) durchgeführt. Ein DNA-Test im Stuhl ist mir nicht bekannt.

Hereditary nonpolyposis colon cancer: genetic basis, testing, and patient-care issues.
AU: Jacobs,-L-A
AD: University of Pennsylvania School of Nursing, Philadelphia, USA.
SO: Oncol-Nurs-Forum. 1998 May; 25(4): 719-25
AB: PURPOSE/OBJECTIVES: To describe the general mechanisms of cancer development and the specific genetic basis for hereditary nonpolyposis colon cancer (HNPCC); to discuss methods of genetic testing, surveillance, and management guidelines; and to review relevant psychosocial issues. DATA SOURCES: Published papers, research reports, and books. DATA SYNTHESIS: Colorectal cancer is one of the most common neoplasms in humans and perhaps the most frequent form of hereditary neoplasia. HNPCC has an autosomal dominant pattern of inheritance with variable but high penetrance estimated to be about 90%. HNPCC underlies 0.5%-10% of all cases of colorectal cancer. CONCLUSIONS: An understanding of the mechanisms behind the development of HNPCC is emerging, and genetic presymptomatic testing, now being conducted in research settings, soon will be available on a widespread basis for individuals identified at risk for this disease. Complex medical, nursing, legal, ethical, and psychosocial issues demand oncology nurses' attention and understanding. IMPLICATIONS FOR NURSING PRACTICE: Oncology nurses in all settings play an integral role assisting patients in (a) understanding their genetic risk status and the implications of genetic testing, (b) making decisions regarding HNPCC genetic predisposition testing, and (c) understanding the meaning of DNA test results. Nurses also may assist patients in understanding and complying with recommended surveillance and management issues.